Premenstrual Dysphoric Disorder – PMDD


Michael E. Platt, M.D.

The following is an excerpt from my soon to be released new book Adrenaline Dominance. 

PMDD  is a condition that has a tremendous impact on the quality of life of the woman who has it –  as well as on the people who surround her. Comparable to the other conditions I have written about, it also falls into the category of ” we don’t know what causes it”. However, when I describe the symptoms, the cause of this disorder will become readily apparent. 

Although  PMDD shares some of the characteristics of PMS, it is in a category all by itself because of the severity of the symptoms. Almost always, the symptoms occur about a week before the period, and are generally resolved about 2 to 3 days after the period starts. 

It is felt to affect about 5% of women who are menstruating. The symptoms always interfere with a woman’s routine functioning –  at school, at work, or in the household. The classic symptoms are generally severe and include the following:

1) extreme mood changes

2) depression with feelings of hopelessness

3) severe anger issues that are often uncontrollable

4) an underlying feeling of pervasive anxiety

5) a feeling of “brain fog” with difficulty focusing

6) trouble falling asleep or staying asleep

7) overwhelming fatigue

8) muscle aches and pains and/or headaches 

Needless to say, all the above symptoms are related to adrenaline. However, PMDD also has additional symptoms that are related to estrogen dominance –  cramps, breast tenderness, fluid retention, and bloating. 

As long as the medical community fails to understand the cause of this condition, it cannot be appropriately treated. It seems that women  are inadequately and poorly treated by doctors who fail to understand how hormones affect  how the body operates. Conditions such as menstrual migraines, postpartum depression, difficulty conceiving, miscarriages, asthma, plus others can be quickly taken care of or eliminated by natural hormone interventions. The treatment of all these conditions are presented in my book, The Miracle of Bio-identical Hormones. 

Getting back to PMDD, the approach to eliminating this condition involves the understanding that the cause is strictly a hormonal problem. The main hormone that needs to be addressed, of course, is adrenaline. 

I suspect that most, if not all, of the women who have this condition are creative types, since these people have the most difficult time with excess adrenaline. The most likely scenario that occurs is as follows: during the week before their cycle the progesterone level is dropping. As a result, the woman’s insulin levels go up leading to periods of hypoglycemia (low blood sugar). The body will respond to this by releasing adrenaline to raise sugar levels for the brain. Adrenaline also causes the release of cortisol, which is a hormone that also raises sugar levels. So now there are two hormones raging sugar levels, which again lead to the release of insulin, which again leads to hypoglycemia, resulting again in the release of adrenaline and cortisol, ad infinitum. 

Of course, the insulin is also contributing to the fluid retention and weight gain, as does the estrogen which is unopposed by progesterone. 

Treatment of this disorder requires a combination of bio-identical progesterone along with a meal plan that helps to lower adrenaline. Progesterone will control the insulin, relieve any symptoms related to estrogen, and will help to block adrenaline. 

A more thorough understanding about how to manage  adrenaline can be obtained by reading  the wellness manual that I wrote for healthcare practitioners, called “The Platt Protocol for Hormone Balancing”. It is only available by going to my website

Finally, as some of you may know, I’m trying to improve healthcare in this country. This can only happen when practitioners change the way they treat patients. They need to start approaching conditions from their cause, and stop giving out Band-Aids. It is unlikely that this will happen unless patient start getting angry, and start asking their doctors to utilize a more logical, effective approach to treating illness.



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